Table 1 Overview of studies on apoptosis in human lung.
From: Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema
| Reference | Patients | COPD defined by | Controls | Increased Apoptosis in patients | Increased Proliferation in patients |
|---|---|---|---|---|---|
| Segura-Valdez [23] | Chronic Bronchitis Emphysema |
-Medical history -Pulmonary Function -Histology/CT | -Male individuals who died from other causes than lung diseases smoking status unknown |
-endothelial cells -alveolar epithelial cells -interstitial cells -inflammatory cells | NA |
| Majo [27] | Emphysema |
-Pulmonary Function -Histology |
-Never smokers -Smokers without emphysema | -No difference between groups | NA |
| Kasahara [28] | Emphysema | -Pulmonary Function | Non smokers | -alveolar epithelial cells | NA |
| -Histology/CT | -Smokers without airway obstruction | -endothelial cells | |||
| Yokohori [25] | Emphysema |
-Pulmonary Function -Histology |
-Asymptomatic smokers -Asymptomatic nonsmokers | -alveolar epithelial cells type II | alveolar epithelial cells type II |
| Imai [24] | Emphysema |
-Pulmonary Function -Histology |
-accidental death victims unused donor lungs for LTX -Smoking status unknown |
-alveolar epithelial cells -endothelial cells -mesenchymal cells | Increased (cell type not specified) |
| Hodge [26] | COPD |
-Medical history -Pulmonary Function | -Never smokers |
-airway epithelial cells (obtained by BAL) -BAL T-cells | NA |