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Figure 1 | Respiratory Research

Figure 1

From: Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

Figure 1

Identification of apoptotic cells in the lung in an animal model of COPD. TUNEL-staining demonstrating an increase in apoptotic cells (dark brown nuclei) in the lungs of mice exposed to cigarette smoke (Figure 1B-C) compared to air-exposed animals (Figure 1A). Double stainings against pro-surfactant-protein C (Figure 1B, alveolar epithelial cells identified as blue pro-surfactant-protein C+ cells) or CD45 (Figure 1C, inflammatory cells identified as blue CD45+ cells) and TUNEL-staining (Figure 1B-C, dark brown nuclei) demonstrating apoptosis of both structural and inflammatory cells (own unpublished data).

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