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Table 4 Arterial blood gases at d15 and d30: Dex- or RA-treated animals at d15 had a respiratory acidosis with hypercarbia (*p < 0.01 vs. saline/controls) and this was maintained in Dex-treated animals at d30 (*p < 0.01 vs. saline/controls). Day 15 animals given Dex + RA did not have respiratory acidosis compared to Dex alone pups (†p < 0.05 vs. Dex alone). Animals at d30 that had been given Dex + RA showed a correction of pH and pCO2 (†p < 0.05 vs. Dex). Only d15 RA-treated animals had significantly lower pO2 values compared to controls (**p < 0.05 vs. saline/controls). Values are expressed mean ± SE.

From: Hormonal regulation of alveolarization: structure-function correlation

Treatment group

pH

pCO2

pO2

Day 15

Control/Saline (n = 6)

7.39 ± 0.03

41.9 ± 3.2

89.8 ± 6.4

Retinoic acid (RA) (n = 4)

7.29 ± 0.03*

54.2 ± 1.6*

67.3 ± 7.1**

Dexamethasone (Dex) (n = 7)

7.27 ± 0.01*

56.3 ± 3.4*

76.0 ± 9.4

Dex + RA (n = 4)

7.31 ± 0.04†

50.1 ± 6.0†

79.3 ± 2.9

Day 30

Control/Saline (n = 12)

7.38 ± 0.01

47.7 ± 1.0

83.5 ± 2.8

Retinoic acid (RA) (n = 10)

7.38 ± 0.01

50.0 ± 1.5

80.1 ± 3.7

Dexamethasone (Dex) (n = 12)

7.33 ± 0.01*

55.5 ± 1.4*

80.9 ± 5.3

Dex + RA (n = 6)

7.38 ± 0.02†

48.5 ± 2.0†

83.7 ± 3.9