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Table 2 Radial alveolar counts (RAC) at d15 and d30: RAC at d15 were significantly lower in Dex-treated and higher in RA-treated pups while Dex + RA animals were similar to controls. At d30, RAC continued to be significantly lower in Dex-treated pups but RA alone increases were lost demonstrating reversal upon stopping treatment. Values are expressed mean ± SE. *p < 0.05 vs. saline-treated animals. †p < 0.01 vs. CSO-treated animals. ‡p < 0.01 vs. d15 RA animals.

From: Hormonal regulation of alveolarization: structure-function correlation

Treatment Group

Day 15

Day 30

Control (n = 3–4)

8.5 ± 0.2

9.0 ± 0.3

Saline (n = 3–4)

8.7 ± 0.3

8.8 ± 0.3

Cottonseed oil (CSO) (n = 3–4)

8.5 ± 0.2

8.8 ± 0.1

Retinoic Acid (RA) (n = 3–4)

11.6 ± 0.2†

8.9 ± 0.1‡

Dexamethasone (Dex) (n = 3–4)

6.6 ± 0.2*

7.3 ± 0.4*

Dex + RA (n = 3–4)

8.9 ± 0.3

8.5 ± 0.2