Figure 2

In-vivo alveolar-capillary protein permeability. Endothelial permeability, evaluated by determining leakage of the vascular marker (¹¹¹In labeled albumin) into the alveoli as assessed by the aspirate radioactivity ratio (Asp/Plasma) (white bars), was significantly increased in PNP group versus control animals (0.28 ± 0.08 vs. 0.03 ± 0.01, p < 0.05). Concomitant rhAPC administration further increased this leakage compared to PNP animals. The accumulation of the vascular protein tracer into the extravascular space of the lung (TPE) (black bars) was increased in the PNP group versus CTR. Concomitant rhAPC administration increased TPE compared to PNP animals. Data are means ± SEM. * p < 0.05 vs. CTR.