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Table 1 Association of maternal atopy* with decreased IL-10 production following innate stimulation (Ppg) in CBMC.

From: Neonatal immune responses to TLR2 stimulation: Influence of maternal atopy on Foxp3 and IL-10 expression

Parameter Stimulus No maternal atopy (Median, 25/75%) Maternal atopy (Median, 25/75%) P value (Mann-Whitney rank)
SI Ppg 1.67 (0.99/2.41) 1.45 (1.13/2.75) 0.97
  Der f1 1.43 (0.98/2.35) 1.38 (0.93/1.95) 0.93
IFN-γ U 2.49 (1.05/5.83) 2.89 (1.86/4.37) 0.57
  Ppg 7.53 (4.70/136.20) 6.07 (2.71/19.19) 0.22
  D 3.70 (1.25/22.38) 9.48 (2.46/18.60) 0.73
IL-13 U 0.01 (0.01/3.39) 0.01 (0.01/3.69) 0.58
  Ppg 8.04 (0.01/46.04) 6.50 (0.01/61.04) 0.91
  D 0.01 (0.01/16.78) 4.10 (0.01/16.96) 0.64
TNF-α U 2.25 (0.01/176.85) 0.27 (0.01/7.60) 0.17
  Ppg 1474.00 (1295.50/1645.00) 1529.00 (1069.12/1694.25) 0.87
  D 758.30 (205.25/1340.25) 782.50 (168.30/1470.00) 0.96
IL-10 U 1.01 (0.52/2.24) 0.38 (0.01/0.77) 0.007
  Ppg 69.54 (25.92/239.78) 13.47 (9.12/86.22) 0.03
  D 10.28 (4.15/14.92) 6.51 (4.25/13.80) 0.68
  1. * Maternal atopy was defined as history of doctors diagnosis of one or more of the diagnoses asthma, hay fever or eczema. N = 31 mothers without and n = 19 mothers with atopy (differs slightly in groups depending on availability of data).
  2. Lymphocyte proliferation is shown as SI (stimulation index, ratio of mean counts per minute of stimulated over unstimulated replicates). Cytokine concentrations were measured with ELISA and are presented in pg/ml.