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Table 2 Slowly adapting pulmonary stretch receptor (PSR) activity and phrenic nerve activity (PNA) during CPAP and PAV before and after lung lavage and after instillation of surfactant.

From: Maintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity

   CPAP PAV CPAP-PAV p (ANOVA)
   Mean±S.D. Mean±S.D.  
Before lung lavage Peak PSR f imp , impulses*sec -1 64 ± 19 67 ± 20 NS
  Time to peak PSR activity, sec 1.48 ± 0.34 1.35 ± 0.10 NS
  PSR f imp per P tp , impulses*sec -1 *kPa -1 1.78 ± 0.33 1.53 ± 0.25 NS
  PNA duration, sec 1.80 ± 0.38 1.64 ± 0.31 NS
  PNA amplitude, AU 0.58 ± 0.50 0.49 ± 0.34 NS
  Mean PNA, AU/sec 0.38 ± 0.42 0.34 ± 0.30 NS
After lung lavage Peak PSR f imp , impulses*sec -1 45 ± 37 a 88 ± 33 a p <0.0001
  Time to peak PSR activity, sec 1.18 ± 0.27 a 0.78 ± 0.22 a p <0.0001
  PSR f imp per P tp , impulses*sec -1 *kPa -1 0.42 ± 0.29 a 0.46 ± 0.19 a NS
  PNA duration, sec 1.38 ± 0.22 a 1.10 ± 0.48a p <0.05
  PNA amplitude, AU 0.68 ± 0.51 0.46 ± 0.40 p <0.03
  Mean PNA, AU/sec 0.53 ± 0.48 a 0.52 ± 0.58 NS
After surfactant instillation Peak PSR f imp , impulses*sec -1 53 ± 36 82 ± 17 p <0.0001
  Time to peak PSR activity, sec 1.00 ± 0.16 b 0.80 ± 0.09 p <0.0001
  PSR f imp per P tp , impulses*sec -1 *kPa -1 0.59 ± 0.25 b 0.55 ± 0.11 b NS
  PNA duration, sec 0.97 ± 0.24 b 0.91 ± 0.09 p <0.01
  PNA amplitude, AU 0.75 ± 0.55 0.61 ± 0.64 NS
  Mean PNA, AU/sec 0.81 ± 0.69 0.67 ± 0.71 b p <0.01
  1. a significant difference between pre- and post-lavage values
  2. b significant difference between post-lavage value and value after surfactant instillation
  3. a,b p < 0.05. ANOVA; two-tailed paired Student's t-test. S.D., standard deviation; NS, non-significant; AU, arbitrary units; PSR fimp, instantaneous impulse frequency of PSR; Ptp, transpulmonary pressure