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Figure 9 | Respiratory Research

Figure 9

From: Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor

Figure 9

Effect of ionomycin on FSK-induced airway relaxation. (A) Airway contraction in response to MCh (200 nM), FSK (10 μM) and ionomycin (5 μM). Ionomycin initially enhanced the relaxation induced by FSK but subsequently re-contracted the airway. Representative traces from 4 experiments from 3 mice. (B) Changes in intracellular Ca2+ and (C) the frequency of the Ca2+ oscillations induced by MCh (200 nM) and FSK (10 μM) followed by exposure to ionomycin. Ionomycin stopped the Ca2+ oscillation and subsequently elevated the [Ca2+]i. Representative traces of five experiments from 4 mice.

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