Figure 12

Effect of FSK on the intracellular Ca²⁺signaling induced by IP₃. The Ca²⁺ signaling of SMCs induced by repetitive flash-photolysis (0.5 s, OD 1.0, arrows) of caged-IP₃ in lung slices incubated (A) without or (B) with FSK for 5 min. Exposure to FSK almost completely abolished the Ca²⁺ response induced by flash photolysis of IP₃. (C) Summary of the changes in Ca²⁺ signaling (peak fluorescence intensity) induced by IP₃ in the slices incubated without or with FSK. The Ca²⁺ signal after exposure to the sHBSS without or with FSK was expressed as a ratio to the Ca²⁺ response before exposure. Data represents the mean ± S.E. from at least 5 different slices from 4 mice. *, p < 0.05.