Figure 6
From: Ca2+-signaling in airway smooth muscle cells is altered in T-bet knock-out mice
Representative traces of ACH-induced Ca2+-signaling. Regions of interest were defined in ASMC in lung slices and the Ca2+-changes in response to ACH (arrow) were expressed as fluorescence ratio F/F0. (A) At low concentrations (10-10 to 10-9 M, 10-9 M for the trace shown), the Ca2+-response consisted of an initial Ca2+-transient followed by baseline Ca2+-oscillations. (B) At higher concentration (≥ 10-8 M, 10-7 M for the trace shown), the Ca2+-response consisted of an initial Ca2+-transient followed by Ca2+-oscillations on an elevated level or (C) followed by a Ca2+-plateau without Ca2+-oscillations (10-6 M for the trace shown).