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Table 1 Patients' characteristics (all patients, for data of subgroups see Results)

From: Lung fibroblasts from patients with emphysema show markers of senescence in vitro

  

Control

Emphysema

n

 

15

 

13

 

Age

yr

62

(54; 67)

64

(58; 70)

Sex

m/f

10/5

 

13/0

 

BMI

kg/m2

24.9

(24.3; 26.6)

22.4

(22.2; 23.9) *

VC

%pred

101.7

(87.2; 110.5)

73.6

(71.6; 90.0) **

FEV1

%pred

94.7

(83.9; 106.3)

37.2

(33.5; 40.7) **

FEV1/VC

%pred

99.0

(94.3; 104.2)

53.2

(44.6; 54.0) **

ITGV

%pred

104.0

(90.2; 117.8)

181.0

(167.0; 222.3) **

RV

L

2.12

(1.86; 2.52)

5.44

(4.53; 6.42) **

TLC

L

6.47

(4.60; 7.05)

8.7

(8.02; 9.89) **

RV/TLC

%

38.1

(32.6; 45.1)

64.1

(54.1; 67.8) **

Smoking history

packyears

25

(20;40)

50

(40;70) *

COPD stage

0/I/II/III/VI

15/0/0/0/0

0/0/1/11/1

DT

h

24.8

(21.7; 25.5)

31.2

(29.3; 40.9) **

  1. The table shows median values and quartiles (in parentheses), *p < 0.05, **p < 0.01 regarding the difference between groups. BMI = body mass index, VC = vital capacity, FEV1 = forced expiratory volume in one second, ITGV = intra thoracic gas volume, RV = residual volume, TLC = total lung capacity, DT = doubling time (time needed for doubling of cell number) of parenchymal lung fibroblasts in culture. Predicted values were taken form ERS guidelines [36] stages of COPD according to GOLD guidelines http://www.goldcopd.com.
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Respiratory Research

ISSN: 1465-993X

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