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Table 1 Patients' characteristics (all patients, for data of subgroups see Results)

From: Lung fibroblasts from patients with emphysema show markers of senescence in vitro

   Control Emphysema
n   15   13  
Age yr 62 (54; 67) 64 (58; 70)
Sex m/f 10/5   13/0  
BMI kg/m2 24.9 (24.3; 26.6) 22.4 (22.2; 23.9) *
VC %pred 101.7 (87.2; 110.5) 73.6 (71.6; 90.0) **
FEV1 %pred 94.7 (83.9; 106.3) 37.2 (33.5; 40.7) **
FEV1/VC %pred 99.0 (94.3; 104.2) 53.2 (44.6; 54.0) **
ITGV %pred 104.0 (90.2; 117.8) 181.0 (167.0; 222.3) **
RV L 2.12 (1.86; 2.52) 5.44 (4.53; 6.42) **
TLC L 6.47 (4.60; 7.05) 8.7 (8.02; 9.89) **
RV/TLC % 38.1 (32.6; 45.1) 64.1 (54.1; 67.8) **
Smoking history packyears 25 (20;40) 50 (40;70) *
COPD stage 0/I/II/III/VI 15/0/0/0/0 0/0/1/11/1
DT h 24.8 (21.7; 25.5) 31.2 (29.3; 40.9) **
  1. The table shows median values and quartiles (in parentheses), *p < 0.05, **p < 0.01 regarding the difference between groups. BMI = body mass index, VC = vital capacity, FEV1 = forced expiratory volume in one second, ITGV = intra thoracic gas volume, RV = residual volume, TLC = total lung capacity, DT = doubling time (time needed for doubling of cell number) of parenchymal lung fibroblasts in culture. Predicted values were taken form ERS guidelines [36] stages of COPD according to GOLD guidelines http://www.goldcopd.com.