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Table 2 Nasal potential difference measurements in mouse nasal epithelium after perfusion with ENaC antisense DNA

From: Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

Baseline PD (mV) Amiloride effect (ΔmV)
Day Control asODN ENaC asODN Control asODN ENaC asODN
  Pre Post Pre Post Pre Post Pre Post
1 15.7 (1.8) 16.3 (1.6) 15.1 (1.8) 20.4 (2.1) -14.3 (1.8) -9.1 (1.3) -14.6 (1.9) -9.7 (1.4)
2 16.9 (2.3) 17.2 (1.7) 16.0 (1.2) 16.3 (2.0) -15.7 (2.3) -13.7 (1.6) -14.8 (1.4) -12.1 (1.3)
3 16.8 (1.9) 17.0 (1.9) 18.0 (1.9) 16.1 (0.9) -12.1 (1.5) -13.0 (2.0) -14.8 (1.4) -12.6 (1.3)
  1. n = 8–10/group. Data are expressed as mean (SEM)
  2. PD = nasal potential difference
  3. Pre = measurements at least 7 to 10 days before administration of control or ENaC asODNs
  4. Post = measurements at the indicated time-points after administration of control or ENaC asODNs.
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Respiratory Research

ISSN: 1465-993X

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