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Table 3 Changes in HAT and HDAC activity and protein expression in asthma and COPD.

From: Epigenetics and airways disease

  HDAC activity HDAC 1 HDAC 2 HDAC 5 HDAC 8 HDAC 3 HAT activity
Asthma ND ND ND
Smoking - - - - -
COPD - 1 1 1 2 -
  1. 1mRNA expression also decreased compared with healthy non-smokers 2mRNA expression also decreased compared with healthy smokers