Table 2 HAT and HDAC family members
HDAC families | Substrate |
|---|---|
    Class I (Rpd3 homologs) | |
   HDAC 1 | H2A, 2B, 3, 4, AR, ER, SHP, YY1 |
   HDAC 2 | H2A, 2B, 3, 4, GR, YY1 |
   HDAC 3 | H2A, 2B, 3, 4, GR, SHP, GATA1, YY1 |
   HDAC 8 | H2A, 2B, 3, 4 |
    Class II (Hda1 homologs) | |
   HDAC 4 | H2A, 2B, 3, 4, GATA1 |
   HDAC 5 | H2A, 2B, 3, 4, GATA1 |
   HDAC 6 | H2A, 2B, 3, 4, tubulin, SHP |
   HDAC 7 | H2A, 2B, 3, 4 |
   HDAC 9 | H2A, 2B, 3, 4 |
   HDAC 10 | H2A, 2B, 3, 4 |
    Class III (Sir2 homologs) | |
   SIRT 1 |  |
   SIRT 2 |  |
   SIRT 3 |  |
   SIRT 4 | Non-histone proteins |
   SIRT 5 | e.g. tubulin, p65, p53 |
   SIRT 6 |  |
   SIRT 7 |  |
    Class IV (Rpd3 homolog) | |
   HDAC 11 | H2A/H2B/H3/H4 |
HAT families | |
    GNATs (Gcn5-related acetyltransferase) | |
   Hat1 | H4/H2A |
   Gcn5 and Gcn5L | H3 K9/K14/H2B, c-Myc |
   Elp3 | H3/H4 |
   Hpa2 | H3/H4 |
   PCAF | H3/H4, c-Myc, GATA2 |
    MYST (MOZ, Ybf2/Sas3, Sas2, Tip60-related) | |
   Esa1 | H4/H2A |
   Tip60 | H4/H2A, c-Myc, AR |
   MOF | H4 K16/H3/H2A |
   MOZ |  |
   Sas3 | H3/H4 |
   Sas2 | H4K16 |
    P300/CBP | |
   P300/CBP | H2A/H2B/H3/H4, p53, p65, AR, ER |
    General transcription factor HATs | |
   TAF250 | H3/H4 |
   TFIIIC | H2A/H3/H4 |
    Nuclear hormone related HATs | |
   SRC1 | H3/H4 |
   SRC3/ACTR | H3/H4 |