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Table 2 HAT and HDAC family members

From: Epigenetics and airways disease

HDAC families Substrate
    Class I (Rpd3 homologs)
   HDAC 1 H2A, 2B, 3, 4, AR, ER, SHP, YY1
   HDAC 2 H2A, 2B, 3, 4, GR, YY1
   HDAC 3 H2A, 2B, 3, 4, GR, SHP, GATA1, YY1
   HDAC 8 H2A, 2B, 3, 4
    Class II (Hda1 homologs)
   HDAC 4 H2A, 2B, 3, 4, GATA1
   HDAC 5 H2A, 2B, 3, 4, GATA1
   HDAC 6 H2A, 2B, 3, 4, tubulin, SHP
   HDAC 7 H2A, 2B, 3, 4
   HDAC 9 H2A, 2B, 3, 4
   HDAC 10 H2A, 2B, 3, 4
    Class III (Sir2 homologs)
   SIRT 1  
   SIRT 2  
   SIRT 3  
   SIRT 4 Non-histone proteins
   SIRT 5 e.g. tubulin, p65, p53
   SIRT 6  
   SIRT 7  
    Class IV (Rpd3 homolog)
   HDAC 11 H2A/H2B/H3/H4
HAT families
    GNATs (Gcn5-related acetyltransferase)
   Hat1 H4/H2A
   Gcn5 and Gcn5L H3 K9/K14/H2B, c-Myc
   Elp3 H3/H4
   Hpa2 H3/H4
   PCAF H3/H4, c-Myc, GATA2
    MYST (MOZ, Ybf2/Sas3, Sas2, Tip60-related)
   Esa1 H4/H2A
   Tip60 H4/H2A, c-Myc, AR
   MOF H4 K16/H3/H2A
   Sas3 H3/H4
   Sas2 H4K16
   P300/CBP H2A/H2B/H3/H4, p53, p65, AR, ER
    General transcription factor HATs
   TAF250 H3/H4
    Nuclear hormone related HATs
   SRC1 H3/H4
   SRC3/ACTR H3/H4
  1. For abbreviations used see text.