Table 4 The reduction in bronchoprotection by fenoterol after terbutaline pre treatment as compared to placebo pre treatment. The response was averaged over fenoterol dose 200–3000 μg. A 50% reduction corresponds to one double dose reduction of PD20 methacholine. Negative numbers indicate an increase in response.
From: Limited β2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics
Reduction in PD20 | ||||
|---|---|---|---|---|
Allelic genotype | Median | 95% CI | P-value | |
I/III | 53% | 31% | 68% | 0.0004 |
III/III | 22% | -24% | 50% | 0.30 |
II/III | 66% | 35% | 82% | 0.0019 |
I/I | -51% | -139% | 4% | 0.078 |
I/II | 50% | -2% | 76% | 0.059 |
II/II | 25% | -106% | 73% | 0.58 |