Figure 1
From: Limited β2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics
PD20 methacholine (mean ± SE) before and after cumulative doses of fenoterol in patients with different genotypes, pre-treated with placebo or terbutaline for two weeks. Averaged over treatment, the shape of the dose response curves varies between the genotypes (p = 0.0011). Averaged over fenoterol dose and genotype, terbutaline pre-treatment reduced PD20 compared to placebo pre-treatment (P = 0.0026). For the reductions in PD20 per genotype and associated p-values: see table 4. Drawn line: placebo pre-treatment, dashed line: terbutaline pre-treatment