Improved outcomes in patients with chronic obstructive pulmonary disease treated with salmeterol compared with placebo/usual therapy: results of a meta-analysis

Table 2 Mean difference in pre-bronchodilator FEV₁ between treatment with salmeterol and with placebo/usual therapy after 3, 6 and 12 months of treatment (intent to treat population).

Study	No. of subjects		Mean treatment effect on pre-bronchodilator FEV₁ (ml)
	Salmeterol	Placebo	3 months	P value	6 months	P value	12 months	P value
van Noord	49	50	108	0.0056	-	-	-	-
Rennard	131	133	74	0.0027	-	-	-	-
Mahler	135	143	128	<0.0001	-	-	-	-
Boyd	228	227	102	<0.0001	-	-	-	-
Mahler	164	185	96	<0.0001	94	<0.0001	-	-
Hanania	176	185	97	<0.0001	92	<0.0001	-	-
Chapman	201	206	42	0.0278	20	0.3559	-	-
Calverley	372	361	80	<0.0001	91	<0.0001	61	0.0022
Stockley	316	318	81	<0.0001	74	0.0002	96	<0.0001
Pooled	1772	1808	86	<0.0001	75	<0.0001	73	<0.0001

ISSN: 1465-993X