Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort

Table 3 Associations between lung function, bronchodilator responsiveness and reflux symptoms and irritable bowel syndrome in women and men.

			Heartburn		Regurgitation		Heartburn and regurgitation		Irritable Bowel Syndrome
		n	Coeff (95% CI)	p	Coeff (95% CI)	p	Coeff (95% CI)	P	Coeff (95% CI)	p
FEV₁/FVC	Women	402	-0.52 (-2.72, 1.68)	0.643	-5.14 (-8.09, -2.20)	0.001	-5.55 (-9.07, -2.04)	0.002	0.04 (-1.58, 1.65)	0.966
	Men	464	0.07 (-1.80, 1.94)	0.942	-0.10 (-2.80, 2.61)	0.944	-0.28 (-3.50, 2.95)	0.866	-0.70 (-2.61, 1.21)	0.473
	p-itn			0.609		0.013		0.029		0.618
		n	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	P	OR (95% CI)	p
BDR	Women	398	3.53 (1.28, 9.70)	0.015	8.74 (2.99, 25.6)	<0.001	11.5 (3.40, 38.6)	<0.001	0.76 (0.25, 2.30)	0.628
	Men	455	1.67 (0.76, 3.68)	0.199	1.11 (0.32, 3.85)	0.864	1.72 (0.48, 6.13)	0.403	1.59 (0.70, 3.61)	0.270
	p-itn			0.256		0.014		0.035		0.300

The FEV₁/FVC ratio is analysed by linear regression and bronchodilator response by logistic regression. Analyses use these as the dependent variables and are adjusted for BMI. Coeff = regression coefficient, OR = odds ratio, 95% CI = 95% confidence intervals, p-itn = p value for interaction between sex and reflux symptoms, BDR = 10% or greater increase in FEV₁ following salbutamol.

ISSN: 1465-993X