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Table 3 Associations between lung function, bronchodilator responsiveness and reflux symptoms and irritable bowel syndrome in women and men.

From: Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort

    Heartburn Regurgitation Heartburn and regurgitation Irritable Bowel Syndrome
   n Coeff (95% CI) p Coeff (95% CI) p Coeff (95% CI) P Coeff (95% CI) p
FEV1/FVC Women 402 -0.52 (-2.72, 1.68) 0.643 -5.14 (-8.09, -2.20) 0.001 -5.55 (-9.07, -2.04) 0.002 0.04 (-1.58, 1.65) 0.966
  Men 464 0.07 (-1.80, 1.94) 0.942 -0.10 (-2.80, 2.61) 0.944 -0.28 (-3.50, 2.95) 0.866 -0.70 (-2.61, 1.21) 0.473
  p-itn    0.609   0.013   0.029   0.618
   n OR (95% CI) p OR (95% CI) p OR (95% CI) P OR (95% CI) p
BDR Women 398 3.53 (1.28, 9.70) 0.015 8.74 (2.99, 25.6) <0.001 11.5 (3.40, 38.6) <0.001 0.76 (0.25, 2.30) 0.628
  Men 455 1.67 (0.76, 3.68) 0.199 1.11 (0.32, 3.85) 0.864 1.72 (0.48, 6.13) 0.403 1.59 (0.70, 3.61) 0.270
  p-itn    0.256   0.014   0.035   0.300
  1. The FEV1/FVC ratio is analysed by linear regression and bronchodilator response by logistic regression. Analyses use these as the dependent variables and are adjusted for BMI. Coeff = regression coefficient, OR = odds ratio, 95% CI = 95% confidence intervals, p-itn = p value for interaction between sex and reflux symptoms, BDR = 10% or greater increase in FEV1 following salbutamol.