Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis

Table 3 Progression with age of lung function within genetic groups stratified according frequency of CFTR mutations.

		Progression with age of lung function	Comparison of progression between genetic groups				Comparison of progressions within groups in relation to ΔF508(2) *		delta of Power analysis 0.8
		Slopes within groups	Intercept at age 6 to 8 yrs mean comparison		Slope differences (age range 6 to 18 yrs)
			F-value	sign.	F-value	sign.	mean diff.	sign.
FRC _pleth	ΔF508(2)	0.151	1.117	n.s.	3.979	0.008
	3905insT/ΔF	0.215					1.057	0.048	0.09154
	R553X/ΔF	0.165					0.120	n.s.	0.09969
LCI	ΔF508(2)	0.247	5.077	0.002	0.491	n.s.
	3905insT/ΔF	0.291					1.865	0.006	0.200854
	R553X/ΔF	0.278					0.307	n.s.	0.236018
V _TG	ΔF508(2)	0.198	3.372	0.019	6.499	0.0001
	3905insT/ΔF	0.233					1.036	0.011	0.113801
	R553X/ΔF	0.256					0.065	n.s.	0.128347
sR _eff	ΔF508(2)	0.405	0.849	n.s.	10.043	0.0001
	3905insT/ΔF	0.549					1.297	n.s.	0.305402
	R553X/ΔF	0.741					3.298	0.039	0.328812
FEV ₁	ΔF508(2)	-0.185	4.542	0.004	13.066	0.0001
	3905insT/ΔF	-0.216					2.502	0.009	0.16809
	R553X/ΔF	-0.466					0.431	n.s.	0.18238
FEF ₅₀	ΔF508(2)	-0.439	1.774	n.s.	14.255	0.0001
	3905insT/ΔF	-0.738					1.011	n.s.	0.30235
	R553X/ΔF	-1.029					2.952	0.002	0.32759
	Misc	-0.354

ISSN: 1465-993X