Figure 1
From: Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury
Effect of leukotrienes pathway pharmacological inhibitionon lung injury. Van Gieson stain: Ć 150. The used stain shows collagen in purple. A: Bleomycin alone in WT mice. B: Magnified lung section of Bleomycin alone in WT mice, Ć 300. C: Bleomycin in MK-571 treated mice. D: Bleomycin in Zileuton treated mice. All showed sections come from the left middle lobe. Each image is representative of at least 3 experiments. E: Lung fibrosis as evaluated by Ashcroft criteria[17]. F: Effect of pharmacological leukotrienes activity inhibition on edema in the lung. Black bar represents control group, grey bar MK-571 group and white bar Zileuton group. Data are means Ā± SEM from 15 mice for each group. *p < 0.01 versus sham. Ā°p < 0.01 vs. bleomycin.