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Table 2 Inflammatory cytokine and chemokine concentrations in airways from CF and wild-type (WT) mice in the absence of induction with P aeruginosa LPS, with and without pre-treatment with azithromycin (10 mg/kg/day), by oral administration, for 4 weeks.

From: Azithromycin reduces spontaneous and induced inflammation in ΔF508 cystic fibrosis mice

  

MIP-2 pg/ml

TNF-α pg/ml

IL-10 pg/ml

CF

AZM-

4.9 ± 0.4

11.8 ± 1.8

84.2 ± 13.9

 

AZM+

5.4 ± 0.7

9.3 ± 1.6

68.1 ± 7.9

WT

AZM-

2.9 ± 0.3

8.1 ± 1.6

42.3 ± 12.1

 

AZM+

3.7 ± 0.4

10.6 ± 2.1

103.0 ± 19.1*

  1. Values are means ± SEM for 9–13 animals per each of the 4 subgroups from pooled data obtained from the same sets of experiments as those used to generate Table 1. * p < 0.025 for comparison of corresponding mean value vs. that obtained for the same parameter in the same group of animal without pre-treatment with azithromycin.