Figure 7

Suggested role of Grxs in cigarette smoke induced oxidative stress. The major function of Grx is the reduction of glutathionylated proteins back to their functional states both intracellularly and in the extracellular space with concomitant release of glutathione. ROS, reactive oxygen species; RNS, reactive nitrogen species; GSH, reduced glutathione; GSSG, oxidized glutathione; GR, glutathione reductase; ELF, epithelial lining fluid.