Cysteinyl-leukotriene and IgE production. A. Cysteinyl-leukotrienes were measured by immunoassay 24 and 48-hours after the last pulmonary challenge; C5-sufficient (solid bars) and C5-deficient (diagonal bars) mice. * indicates p < 0.05 for C5-sufficient compared to C5-deficient at the indicated time point, p = 0.015 at 24-hours and p = 0.003 at 48-hours. B. Total plasma IgE was determined by ELISA. Each value is the mean ± SEM for three experiments; n = 5 mice/group at 24-hours and n = 10 mice/group at 48-hours, p > 0.05 for C5-sufficient compared to C5-deficient at each time point.