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Figure 4 | Respiratory Research

Figure 4

From: Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation

Figure 4

Bronchodilation effect of CFTR activators on rat trachea. Typical traces from experiments performed with tracheal rings preconstricted with 1 μM CCH. A The effect on tension of various concentrations of MPB-91. B Concentration-dependent curves are displayed, showing the bronchodilation of tracheal rings preconstricted by 1 μM CCH for MPB-91 in absence (IC50 = 42 ± 5 μM, n = 13) or in presence of 10 μM CFTRinh-172 (IC50 = 71 ± 3 μM, n = 6), or 100 μM CFTRinh-172 (IC50 > 150 μM, n = 7). C The effect on tension of various concentration of MPB-07. D Concentration-dependent curves showing the bronchodilation of tracheal rings preconstricted by 1 μM CCh for MPB-07 in absence (IC50 = 94 ± 4 μM, n = 16) or presence (IC50 = 87 ± 5 μM, n = 15) of 100 μM L-NAME (pre-incubated 30 min). E The effect on tension of various concentrations of MPB-80. F Concentration-dependent curves are displayed, showing the bronchodilation of tracheal rings preconstricted by 1 μM CCH for MPB-80 (IC50 = 135 ± 5 μM, n = 8).

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