Figure 4From: Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilationBronchodilation effect of CFTR activators on rat trachea. Typical traces from experiments performed with tracheal rings preconstricted with 1 μM CCH. A The effect on tension of various concentrations of MPB-91. B Concentration-dependent curves are displayed, showing the bronchodilation of tracheal rings preconstricted by 1 μM CCH for MPB-91 in absence (IC50 = 42 ± 5 μM, n = 13) or in presence of 10 μM CFTRinh-172 (IC50 = 71 ± 3 μM, n = 6), or 100 μM CFTRinh-172 (IC50 > 150 μM, n = 7). C The effect on tension of various concentration of MPB-07. D Concentration-dependent curves showing the bronchodilation of tracheal rings preconstricted by 1 μM CCh for MPB-07 in absence (IC50 = 94 ± 4 μM, n = 16) or presence (IC50 = 87 ± 5 μM, n = 15) of 100 μM L-NAME (pre-incubated 30 min). E The effect on tension of various concentrations of MPB-80. F Concentration-dependent curves are displayed, showing the bronchodilation of tracheal rings preconstricted by 1 μM CCH for MPB-80 (IC50 = 135 ± 5 μM, n = 8).Back to article page