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Table 1 A semiquantitative analysis of lung damage by histopathological scores.

From: Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline

 

Negative control

Untreated

Pure CS

Thio-CS

TPL

TPL + Pure CS

TPL + Thio-CS

Epithelium

0.8 ± 0.3

2.5 ± 0.3

2.1 ± 0.2

2.0 ± 0.2

1.8* ± 0.2

1.6* ± 0.2

1.2** ± 0.2

Peribroncho-vascular infiltrate

0.4 + 0.2

2.1 ± 0.4

2.0 ± 0.4

1.9 ± 0.1

1.4* ± 0.2

1.4* ± 0.4

0.8** ± 0.2

Interstitial-alveolar cell infiltrate

0.7 ± 0.2

2.3 ± 0.3

2.0 ± 0.4

2.0 ± 0.2

1.6 ± 0.3

1.4* ± 0.2

0.9** ± 0.2

  1. **p < 0.01 compared with the untreated group
  2. *p < 0.05 compared with the untreated group