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Figure 3 | Respiratory Research

Figure 3

From: Magnetic resonance lung function – a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial

Figure 3

Upper image and graph: patient with normal pulmonary function test. On the left, a MR ventilation image is shown with the 6 ROIs (in different colours) used for ventilation measurement, on the right are the ventilation graphs which show the ventilation (= ml air/ml lung parenchyma) in 50 images for each ROI during the respiratory cycles. The 50 measurements span a total of one minute. The colours of the graphs match the colours of the ROIs in the ventilation image to differenciate the 6 lung regions. The ventilation is similar in each of the ROIs. Note the tiring of the young patient (maximal in- and expiration at the beginning only). Ventilation measurements: Right: upper field (turquoise) 0.64 ml/cm3; middle field (violet) 0.68 ml/cm3; lower field (brown) 0.65 ml/cm3. Left: upper field (yellow) 0.67 ml/cm3; middle field (pink) 0.68 ml/cm3; lower field (blue) 0.62 ml/cm3. Middle image and graph: patient with cystic fibrosis. The total ventilation is markedly decreased compared to the healthy patient. Additionally, the different lung regions show a very different ventilation, poorest in the left middle field. Ventilation measurements: Right: upper field (turquoise) 0.27 ml/cm3; middle field (violet) 0.17 ml/cm3; lower field (brown) 0.3 ml/cm3. Left: upper field (yellow) 0.2 ml/cm3; middle field (pink) 0.32 ml/cm3; lower field (blue) 0.38 ml/cm3. Bottom Graph: Correlation of MR ventilation and vital capacity measured by conventional pulmonary function test (r = 0,8; p ≤ 0,001). Black lines = regression line and 95% confidence interval.

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