Figure 4
From: Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma
Effect of the pretreatment with montelukast on salbutamol-induced relaxation in challenged human bronchial rings. Relaxant responses to salbutamol in carbachol-contracted human bronchial rings. Values of 100 and 0 on y-axis represent maximal force in response to 10-6M carbachol and minimal force at 10-4M salbutamol, respectively. ▲, sensitized control rings (n = 5); ■, challenged-untreated rings (n = 6); ○, montelukast 10-7M-treated rings (n = 5); □, montelukast 10-6M-treated rings (n = 5). The results are presented as mean ± S.E.M. *P < 0.05 (two-way repeated-measure ANOVA followed by Bonferroni post-hoc test) ■ vs. ▲, ○, and □.