Figure 3
From: Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma
Effect of exogenous LTD 4 challenge on isoproterenol- or forskolin-induced cAMP accumulation in HASMC. A. Effects of LTD4 (10-6M) challenge and pretreatment with the PKA inhibitor H89 (10-6M) on cAMP accumulation induced by single (10-5M) isoproterenol concentration in HASMC. B. Effects of LTD4 (10-6M) challenge on cAMP accumulation induced by single (10-4M) forskolin concentration in HASMC. The results are presented as mean ± S.E.M. of at least two experiments performed in triplicate. **P < 0.01, *P < 0.05 (oneway ANOVA).