Skip to main content
Figure 1 | Respiratory Research

Figure 1

From: Cysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma

Figure 1

Effect of exogenous LTD 4 or PMA challenge on isoproterenol-induced cAMP accumulation in HASMC. A-B. Effects of leukotriene D4 (LTD4, 10-6M) challenge and pretreatment with the CysLT1R antagonist montelukast (MK, 10-6M) on cAMP accumulation induced by multiple (A) and single (B, 10-5M) isoproterenol concentrations in HASMC. C. Effect of phorbol-12-myristate-13-acetate (PMA, 5 × l0-7M) challenge and pretreatment with the PKC inhibitor GF109203X (10-6M) on cAMP accumulation induced by 10-5M isoproterenol in HASMC. The results are presented as mean ± S.E.M. of at least three experiments performed in triplicate. **P < 0.01 (one-way ANOVA).

Back to article page