Table 4 Effects of dexamethasone and MK-571 on 5-LO pathway enzymes and LT receptors in HBFs.
From: Human bronchial fibroblasts express the 5-lipoxygenase pathway
Enzymes/Receptors | Control* | Dexamethasone | MK-571 |
|---|---|---|---|
5-LO | 7.6 ± 2.2 | 5.7 ± 2.0† | 7.5 ± 2.6 |
FLAP | 9.3 ± 3.3 | 6.3 ± 2.5 | 5.3 ± 2.0‡ |
LTA 4 H | 7.8 ± 2.1 | 5.3 ± 1.6† | 5.2 ± 0.9 |
LTC 4 S | 0.3 ± 0.2 | 0.7 ± 0.4 | 0.5 ± 0.2‡ |
BLT1 | 4.8 ± 1.1 | 4.5 ± 1.3 | 3.9 ± 0.9 |
CysLT 1 | 11.7 ± 3.5 | 5.6 ± 1.4 | 16.0 ± 6.9 |