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Table 2 PFTs results of 100 SSc patients

From: Functional, radiological and biological markers of alveolitis and infections of the lower respiratory tract in patients with systemic sclerosis

  FVC ≤ 79%
DLCO ≤ 79%
16 patients
FVC ≥ 80%
DLCO ≤ 79%
74 patients
FVC ≥ 80%
DLCO ≥ 80%
10 patients
Age (years), mean ± sd 55.1 ± 12.4 56.1 ± 11.9 50.7 ± 11.4
Disease duration (years), median (I.Q. range) 7 (4 – 18) 6 (3 – 13) 4.5 (1 – 14.5)
Sex n (%) 14 F (87.5%)
2 M (12.5%)
68 F (91.9%)
6 M (8.1%)
10 F (100.0%)
0 M (0.0%)
Skin involvement:    
dSSc n (%) 12 (75.0%) 12 (16.2%) 0 (0.0%)
lSSc n (%) 4 (25.0%) 62 (83.8%) 10 (100.0%)
Skin score mean ± sd 14.8 ± 10.7 9.9 ± 7.4 6.7 ± 4.6
Autoantibodies pattern:    
ACA n (%) 2 (12.5%) 32 (43.2%) 7 (70.0%)
AntiScl 70 n (%) 11 (68.7%) 25 (33.8%) 2 (20.0%)
Antinucleolus n (%) 0 (0.0%) 9 (12.2%) 1 (10.0%)
AntiRNP n (%) 1 (6.3%) 5 (6.8%) 0 (0.0%)
ACA/Scl 70/nucleolus/RNP negative n (%) 2 (12.5%) 3 (4.0%) 0 (0.0%)
FVC (%) mean ± sd 65.0 ± 8.8 104.8 ± 16.3 122.0 ± 13.3
≤ 69% n (%) 12 (75.0%) 0 (0.0%) 0 (0.0%)
≤ 49% n (%) 1 (6.3%) 0 (0.0%) 0 (0.0%)
DLCO (%) mean ± sd 39.8 ± 11.8 59.0 ± 10.4 94.2 ± 12.6
≤ 69% n (%) 16 (100%) 67 (90.5%) 0 (0.0%)
≤ 49% n (%) 13 (81.3%) 16 (21.6%) 0 (0.0%)
FVC and DLCO ≤ 69% 12 (75.0%) 0 (0.0%) 0 (0.0%)
FVC and DLCO ≤ 49% 1 (6.3%) 0 (0.0%) 0 (0.0%)
PASP ≥ 40 mmHg n (%) 6 (37.5%) 5 (6.7%) 0 (0.0%)
≥ 60 mmHg n (%) 1 (6.3%) 1 (1.3%) 0 (0.0%)
  1. PFTs: pulmonary function tests; FVC: forced vital capacity; DLCO: diffusing capacity for carbon monoxide; dSSc: diffuse skin involvement; lSSc: limited skin involvement; ACA: anticentromere antibodies; antiScl 70: antitopoisomerasi I antibodies; antiRNP: antiribonucleoproteins antibodies; PASP: pulmonary artery systolic pressure.