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Figure 1 | Respiratory Research

Figure 1

From: Identification of HLA-DRPheβ47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGluβ69

Figure 1

Inhibition of beryllium (BeSO4)-induced proliferation, by MoAbs directed against HLA-DR, HLA-DP, HLA-DQ, HLA-class I and the 19 kDa M. tuberculosis protein in PBMC from BH subjects carrying or not the HLA-DPGlu69 and the HLA-DRPhe47 markers. They were 4 HLA-DPGlu69 negative/HLA-DRPhe47 positive (3 sensitized and 1 berylliosis affected), 3 HLA-DPGlu69 positive/HLA-DRPhe47 negative (0 sensitized and 3 berylliosis affected) and 8 HLA-DPGlu69 positive/HLA-DRPhe47 positive (3 sensitized and 5 berylliosis affected). On the ordinate is shown the percentage of inhibition (with respect to the MoAbs untreated cells) of T-cell proliferation obtained by co-culturing the PBMC from berylliosis patients with BeSO4 in the presence of each MoAb reported on the abscissa (anti-HLA-DR: DR, anti-HLA-DP: DP, anti-HLA-DQ: DQ, anti-HLA-class I: C.I, anti-19 kDa M. tuberculosis: Mtb).

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