Skip to main content

Table 1 Patients' characteristics

From: A role for MCP-1/CCR2 in interstitial lung disease in children

No Sex Age [years] Interstitial lung disease Diagnosis finding Radiographic findings Fibrotic changes (CT) ILD Score* Dyspnoe Cough Cyanosis Exercise Intolerance Failure to thrive Medication FVC [% of pred.] TLC % [of pred.]
1 F 7 LIP CT, LB • diffuse interstitial involvement + 4 ++ + + + + CS, AZT 34 56
      • reticular-nodular pattern           
      • follicular bronchiolitis           
2 M 14 U-ILD, IPH CT, BAL patchy interstitial involvement - 2 + - - - - CS 77 89
3 M 8 U-ILD CT, LB • ground-glass opacity + 3 ++ - - + -   46 74
4 M 4 IPH CT, BAL, LB interstitial involvement - 3 + - - - -   77 168
5 M 16 U-ILD CT, BAL interstitial involvement + 2 + - - + +   76 95
6 F 7 U-ILD CT, BAL interstitial involvement - 2 + + - - + AZT 50 68
7 M 4 CPI CT, LB • diffuse infiltrates + 3 + - - + + AZT 58 64
      • ground-glass opacity           
8 F 3 NSIP CT, LB • interstitial involvement + 3 ++ - + + + CS n.d. n.d.
      • alveolar infiltrates           
9 M 8 Sarcoidosis CT, BAL, LB • interstitial involvement + 2 ++ + - + + CS 56 63
      • perivascular nodules           
10 F 8 U-ILD CT, BAL, LB ground-glass opacity - 1 - + - + -   76 87
11 F 8 CPI CT, LB • interstitial involvement + 2 + + - + + CS 37 74
      • ground-glass opacity           
12 M 9 U-ILD CT interstitial involvement - 2 + - - - -   70 98
13 M 5 NSIP CT, LB • interstitial involvement + 3 ++ - - + - CS 61 76
      • ground-glass opacity           
14 F 6 U-ILD CT reticular-nodular pattern + 3 ++ + - - - AZT 60 68
15 F 4 U-ILD CT interstitial involvement + 2 + + - - +   n.d. n.d.
16 M 12 U-ILD CT interstitial involvement - 2 + - - - -   68 75
17 M 3 PAP† CT, BAL, LB • ground glass opacity - 4 +++ + + + + CS n.d. n.d.
18 M 6 NSIP CT, BAL, LB • alveolar infiltrates + 4 +++ + + + + CS, AZT 63 72
    PAP   • ground glass opacification           
19 F 3 PAP† CT, BAL, LB • ground glass opacity + 4 ++ - + + + CS n.d. n.d.
      • alveolar infiltrates           
20 F 9 NSIP CT, LB • interstitial involvement + 3 ++ + + + + CS, AZT 55 74
      • honeycombing           
21 M 7 U-ILD CT reticular-interstitial pattern + 3 + + - + + AZT, MT 38 59
22 M 7 Cholesterol CT, BAL, LB • interstitial involvement + 4 +++ + + + + CS 16 24
    pneumonitis†   • reticular-interstitial pattern           
23 M 4 U-ILD CT, LB • interstitial involvement - 2 + - - + + CS 102 99
      • honeycombing           
24 M 8 U-ILD CT interstitial involvement - 2 + + - + - CS 63 78
25 M 7 NSIP CT, LB • interstitial involvement + 3 + + - + - CS 60 76
  1. ILD-NC: children with interstitial lung disease without systemic corticosteroid treatment; ILD-C: children with interstitial lung disease with systemic corticosteroid treatment;
  2. U-ILD: undefined/idiopathic interstitial lung disease: no specific diagnosis could be made; PAP: pulmonary alveolar proteinosis; CGD: chronic granulomatous disease; IPH: idiopathic pulmonary hemosiderosis; LIP: lymphocytic interstitial pneumonia; CPI: Chronic pneumonitis of infancy
  3. CS: corticosteroids, AZT: azathioprine, MT: methotrexat
  4. n.d.: lung function testing not done (children < 5 years); † symbolizes patients who died due to respiratory failure.
  5. CT: Computed tomography; BAL: Bronchoalveolar lavage; LB: Lung biopsy
  6. * ILD score according to Fan[41]