Figure 6

Reduced chemoattractant production and MMP activity in wild-type mice upon PPARα activation by fenofibrate. Chemoattractant levels (A) and MMP-2 and MMP-9 activity (B) in BALF from C57BL/6 mice exposed to LPS and treated with fenofibrate (15 mg/day, black bars) or its vehicle (1% CMC, grey bars), when compared to mice exposed to saline and treated with CMC (open bars). Data are mean ± SEM of n = 7–8 animals. Statistically significant differences at α = 0.05: (*) when compared to mice exposed to saline and treated with CMC; (#) when compared to mice exposed to LPS and treated with CMC.