Table 2 Summary of genes up regulated by IL-13 and IL-13R130Q.
Category | Gene(s) | Fold change |
|---|---|---|
Airway Inflammation | ||
Adhesion Molecules | VCAM-1 | ↑ 2 fold |
ALCAM | ||
Selectin P ligand | ||
Laminin B1 | ||
Chemokines | Chemokine Ligand 2 | |
Chemokine Ligand 11 | ||
Chemokine Ligand 26 | ||
Chemokine Ligand 27 | ||
Cytokine receptors | IL-13 Rα2 | ↑ 1.6 fold |
Interleukin 1 receptor | ||
Airway Remodeling | ||
Extracellular matrix | Tenascin C | ↑ 2 fold |
Tenascin R | ||
Collagen Type I | ||
Collagen Type VI | ||
Collagen Type III | ||
Fibulin 1 | ||
CD44 | ||
Cell proliferation | Pim-1 | |
eEF1A | ||
Cytokines | PDGFC | |
Retinoic acid Receptor | ||
Interferon beta 1 | ||
Bronchial Hyper-responsiveness | ||
Cytoskeletal constituants | Vimentin | |
Tropomyosin 1 | ||
Tropomyosin 2 | ||
Actin | ||
Calcium regulators | Phospholipase D | |
Calreticulin | ||
hGIRK1 | ||
TRPC4 | ||
TRPC6 | ||
Sphingosine kinase 1 | ||
Rho GDP dissociation inhibitor | ||
FKBP1A | ||
Receptor | Histamine H1 receptor | ↑ 1.3 fold |