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Table 2 Summary of secondary endpoints at baseline and week 48

From: Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease

  Losartan Placebo  
  Baseline
(n = 20)
End of study
(n = 16)
Change Baseline
(n = 20)
End of study
(n = 18)
Change p-value
Right atrial pressure (mmHg) 4.0 (0.8) 4.0 (0.6) -0.1 (1.0) 4.1 (0.9) 3.8 (0.0) -0.4 (1.0) 0.56
Peak tricuspid regurgitant velocity (m/s) 3.3 (0.3) 3.2 (0.6) +0.0 (0.7) 3.3 (0.4) 3.5 (0.5) +0.2 (0.4) 0.37
RV systolic pressure (mmHg) 46.9 (8.9) 47.3 (14.5) +0.7 (16.8) 47.5 (10.0) 52.5 (13.4) +4.7 (10.9) 0.41
LV fractional shortening (%) 33 (8) 36 (7) +2.5 (8.6) 31 (6) 32 (9) +1.8 (9.7) 0.84
RV wall thickness (mm) 4.1 (0.8) 4.4 (1.3) +0.4 (1.1) 4.0 (0.6) 4.2 (0.6) +0.3 (0.6) 0.69
  1. Between group p-value for the difference in change from baseline.
  2. LV= left ventricular. RV = right ventricular.