TY - JOUR AU - Schaafsma, Dedmer AU - Gosens, Reinoud AU - Bos, I. Sophie T. AU - Meurs, Herman AU - Zaagsma, Johan AU - Nelemans, S. Adriaan PY - 2005 DA - 2005/07/27 TI - Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction JO - Respiratory Research SP - 85 VL - 6 IS - 1 AB - In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously found to be dependent on Rho-kinase and have also been associated with the production of eicosanoids. However, the precise mechanisms underlying growth factor-induced contraction are still unknown. In this study we investigated the role of contractile prostaglandins and Rho-kinase in growth factor-induced ASM contraction. SN - 1465-993X UR - https://doi.org/10.1186/1465-9921-6-85 DO - 10.1186/1465-9921-6-85 ID - Schaafsma2005 ER -