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Table 4 Pro-SP-B and pro-SP-C in 15 children with pulmonary alveolar proteinosis

From: Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease

 

pro-SP-B

pro-SP-C

Detecting antibody

CTERMB

CFLANK

NFLANK

NFPROX

NPROSP-C-C2

Mr of bands(kDa)

     

40–42

7% [5]

-

-

-

-

34–36

7% [5]

-

-

-

-

25–26

93% [1–5,7–15]

20% [3,5,15]

87%+ [1–5,7–12,14,15]

-

-

19–21

87%* [1–5,7–13,15]

7% [5]

20% [4,5,9]

7% [4]

7% [8]

15

7% [8]

-

7% [8]

33%+ [2,8,9,11,12]

7% [8]

13

-

-

-

20% [3,8,9]

-

12

-

-

7% [14]

-

-

11

-

7% [14]

-

-

7% [8]

9

-

7% [10]

14% [5,10]

-

-

6

-

-

-

-

7% [4]

  1. Percent of subjects with bands and identification numbers of those subjects in whom bands reacting with the anti-pro-SP-B-antibodies CTERMB, NFLANK, CFLANK, NFPROX and displaced by the CTERMB, NFLANK, CFLANK, NFPROX peptides, or the anti-pro-SP-C-antibody NPRO-SP-C-C2 and displaced by the respective peptide, were identified. Differences in the frequency of bands of all the disease groups were evaluated by the Fisher exact test and those with a P ≤ 0.05 were indicated by an * for comparison with the healthy control group or by a + for comparison with the disease control group, bronchitis (see table 2). The identification numbers of the patients are given in square brackets []. Numbers in bold indicate bands not identified by the CTERMB antibodies.