Serum biomarkers in interstitial lung diseases

Respiratory Research

Table 8 Scoring of various clinical utilities for key biomarkers in ILDs

Clinical Utilities	Key Biomarkers
	KL-6	SP-A	SP-D	CC16	sIL-2R	ACE	TNFa
Detection of lung disease	+ +	+ +	+ +	+	NE	+ +	+ +
Histospecific diagnostic accuracy	+ / -	+	+ / -	NE	NE	+	NE
Correlation with disease severity	+ +	+	+ +	+	+ +	+	+ +
Prediction of response to therapy	+	+ / -	+ / -	NE	NE	+ / -	NE
Prediction of decline	+	+ / -	+	+ / -	+	+ / -	+ / -

Abbreviations: ACE: Angiotensin Converting Enzyme, CC16: Clara-cell protein 16, KL-6: Krebs von den Lungen-6, LDH: Lactate Dehydrogenase, ILDs: Interstitial Lung Diseases, ILDs: Interstitial Lung Diseases, sIL-2R: soluble interleukin-2 receptor, SP: Surfactant Protein, TNF: Tumor Necrosis Factor NE: Not Evaluated, 0: No utility, + / -: Low, +: Moderate, + +: High Utility

ISSN: 1465-993X