Table 6 Studies measuring serum biomarkers in patients with other ILDs
Investigator | Patients Controls | Biomarker / Summary | ROC curve analysis Cut-off values | Specificity – Sensitivity Diagnostic accuracy | Limitations |
|---|---|---|---|---|---|
Ohnishi et al. 92 | 30 | Elevated circulating KL-6 levels in patients with drug induced pneumonitis | No KL-6: 520 U/ml | Sensitivity: 53 – 89% | Small number of patients / Discrepancies with CT features |
Kohno et al. 93 | 15 | Circulating antigen KL-6 and LDH for monitoring irradiated patients with lung cancer | No | Not estimated | Small number of patients / Retrospective study / Evaluation of serial measurement not definitive |
Goto et al. 94 | 16 | Serum levels of KL-6 are useful biomarkers for severe radiation pneumonitis | No | Not estimated | Small number of patients / Retrospective study / Chemotherapy influence |
Takahashi et al.95 | 25 | Diagnostic significance of SP-A and SP-D in sera from patients with radiation pneumonitis | No | Sp-A: 83 - 85% Sp-D: 83 - 85% | Small number of patients / Chemotherapy influence / No long term follow-up / Non ILD-specific markers |
Al-Salmi et al. 97 | 10 10 | Elevated serum KL-6 and SP-A and SP-D in pediatric ILDs | No | Not estimated | Small number of patients / Diversity of the diseases studied / Poor correlation with functional and radiological parameters |