Figure 5
Elastic fiber concentration (mm length / mm3parenchyma) was decreased in VAD rats and was restored by retinoic acid (RA)-administration. The length (mean ± SEM) of elastic fibers per unit volume was decreased in lungs from VAD (n = 9 sections analyzed) rats compared to lungs from VAS rats (n = 11) that were fixed at the same pressure (*) p < 0.05, 1-way ANOVA, Student-Newman-Keuls post-hoc test. The fiber concentration in VAD rats that received RA for 12 days (VAD + 12d RA, n = 6) was significantly greater than for VAD (#), p < 0.05. 3 rats were used for each retinoid-treatment group.