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Figure 5 | Respiratory Research

Figure 5

From: CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II

Figure 5

Time course of spontaneous and cytokine-induced (A ) CCL2 and (B ) CXCL10 production by primary cultured AEC-II. IL-1β, but not IFN-γ increases CCL2 release, whereas both IL-1β and IFN- increase CXCL10 release in a time- and dose-dependent manner. The increase induced by IL-1β is about 10-fold lower compared with the CXCL10 levels induced by IFN-γ at the same concentrations and time points. The distinct dots on the lines represent means of triplicate determinations at each time-point for different concentrations of cytokine. *P < 0.05 compared to spontaneously produced chemokine levels by AEC-II. Data are representative results from three independent experiments.

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