Table 3 Anion selectivity sequence of the perfused bronchiole. The sequence of the bronchiole (upper data) roughly fits the known sequence of CTFR in other tissues (lower data taken from literature; cf. text)
From: Predominant constitutive CFTR conductance in small airways
Airway Anion selectivity: | Cl- | ≈ | Br- | > | I- | > | NO3 - | > | HCO3 - | >> | Gluconate |
|---|---|---|---|---|---|---|---|---|---|---|---|
Transepithelial TEP : | ~0 | -1.9 | -5.1 | -9.2 | -19.5 | -44.8 | |||||
Estimated Px/PCl: | 1.0 | 0.92 | 0.79 | 0.65 | 0.33 | 0.28 | |||||
CFTR anion selectivity: | NO 3 - | ≈ | Br - | ≈ | Cl - | > | I - | > | HCO 3 - | >> | Gluconate |
Estimated Px/PCl: | 1.1 | 1.1 | 1.0 | 0.39 | 0.014 | ~0 |