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Table 1 Summary of features of ABC transporters in human lung.

From: ATP-binding cassette (ABC) transporters in normal and pathological lung

ABC gene

Gene location

Functional role or substrates

Linked to disease

Protein expression in lung cells

(+ localisation $ )

References #

MDR1/P-gp (ABCB1)

7q21.12

Drug resistance, Hydrophobic organic cations

Unknown

Bronchial epithelium (ap), mucinous glands (ap), alveolar type I cells* (ap), endothelium* (ap), alv. macroph.

[4,12,14-16]

MDR3/P-gp (ABCB4)

7q21.12

Phosphatidyl choline

Unknown

Absent

[4]

MRP1 (ABCC1)

16p13.12

Drug resistance, Organic anions (e.g. GSH conjugates, LTC4)

COPD?

Bronchial epithelium (ba/la), goblet cells (ba), peripheral epithelial cells* (ba/la), seromucinous glands (ba/la), alv. macroph.

[4,53,85]

MRP2 (ABCC2)

10q24.2

Drug resistance, Organic anions

Dubin-Johnson syndrome

Bronchial epithelium* (ap), primary bronchial and peripheral epithelial cells* (in)

[4,85,90]

MRP3 (ABCC3)

17q21.33

Drug resistance, Organic anions

Unknown

Primary bronchial and peripheral epithelial cells* (ba/la)

[85]

MRP4 (ABCC4)

13q32.1

Nucleoside analogues, Prostaglandin E1, E2

Unknown

Primary bronchial and peripheral epithelial cells* (in)

[85]

MRP5 (ABCC5)

3q27.1

Nucleoside analogues, Hyaluron

Unknown

Primary bronchial and peripheral epithelial cells* (in)

[85]

MRP6 (ABCC6)

16p13.12

Unknown

Pseudoxanthoma elasticum

Unknown

 

MRP7 (ABCC10)

6p21.1

Drug resistance

Unknown

Unknown

 

MRP8 (ABCC11)

16q12.1

Conjugated steroids, Nucleoside analogues, bile acids

Unknown

Unknown

 

MRP9 (ABCC12)

16q12.1

Unknown

Unknown

Unknown

 

CFTR (ABCC7)

7q31.31

Chloride ion channel

Cystic fibrosis

Bronchial epithelium (ap), seromucinous glands (ap), Clara cells*, Alv. type I cells*

[117-120]

BCRP (ABCG2)

4q22

Drug resistance, Protection food toxins

Unknown

Bronchial epithelium (ba/la), endothelium, seromucinous glands

[4]

ABCA1

9q31.1

Cholesterol and phospholipids

Tangier disease

Alv. type II cells

[151]

ABCA3

16p13.3

Surfactant secretion

Surfactant deficiency

Alv. type II cells

[155]

  1. $Cellular localisation: ap, apical; ba, basal; la, lateral; in, intracellular; alv., alveolar; macroph., macrophages;#References are mentioned that demonstrate protein localisation histologically; *Conflicting results exist in literature.