Figure 2

Effect of genetic or pharmacological inhibition of iNOS on edema in the lung. The injection of bleomycin in iNOSWT mice elicited an inflammatory response characterized by the accumulation of water in lung as an indicator of edema. The genetic or pharmacological inhibition of iNOS significantly reduced the edema formation. Data are means ± s.e. means from 10 mice for each group. *p < 0.01 versus sham. °p < 0.01 represents significant reduction of the various parameters in the group in which iNOS was inhibited or absent.