Figure 1

Effect of iNOS inhibition on lung injury. H&E stain: × 250. A: Saline control, normal lung architecture. B: Bleomycin alone in iNOSWT mice, extensive inflammation with inflammatory cells infiltration and fibrosis. C: Bleomycin in iNOSKO mice patchy areas of inflammation with minimal fibrosis. D: Bleomycin in iNOSWT mice plus GW274150 patchy areas of inflammation with minimal fibrosis. Comparable sections of mouse lung stained with trichrome: A1: saline control: normal lung architecture; B1; Bleomycin alone in iNOSWT mice, extensive areas of collagen; C1: Bleomycin in iNOSKO mice minimal collagen; D1: Bleomycin in iNOSWT mice plus GW274150 minimal collagen. Figure is representative of at least 3 experiments performed on different experimental days.