Skip to main content

Table 1 Characteristics of included studies

From: Respiratory rehabilitation after acute exacerbation of COPD may reduce risk for readmission and mortality – a systematic review

Study Population Intervention Follow up Outcomes
Behnke 2000 [19] and 2003 [20] 26 COPD patients (mean age 67 years, 77% males, mean FEV1 = 36% predicted) after inpatient treatment for acute exacerbation. Rehabilitation: Within 4–7 days after admission, inpatient respiratory rehabilitation with endurance exercise (5 walking sessions/day for 10 days), followed by six months of supervised home-based endurance exercise (3 walking sessions/day for 6 months)
Usual care: Standard inpatient care without exercise and standard community care with respirologist.
18 months CRQ, Transition dyspnea index, 6 MWT, hospital readmission, mortality
Kirsten 1998 [22] 29 COPD patients (mean age 64 years, 90% males, mean FEV1 = 36% predicted) after inpatient treatment for acute exacerbation. Rehabilitation: Within 6–8 days after admission, inpatient respiratory rehabilitation with endurance exercise (5 walking sessions/day for 10 days).
Usual care: Standard inpatient care without exercise.
11 days Transition dyspnea index, 6 MWT
Man 2003 [24] 42 COPD patients (mean age 70 years, 41% males, FEV1 = 39% predicted) after inpatient treatment for acute exacerbation. Rehabilitation: Multidisciplinary outpatient respiratory rehabilitation (within 10 days of discharge) with endurance and strength exercise and patient education for 12 weeks (2 sessions/week).
Usual care: Standard community care with respirologist
12 weeks CRQ, SGRQ, Short form survey 36, shuttle walk test, hospital readmission, hospital days, emergency admissions, mortality
Murphy 2005 [21] 26 COPD patients (mean age 66 years, 65% males, mean FEV1 = 40% predicted) after home for hospital treatment for acute exacerbation. Rehabilitation: Supervised home-based respiratory rehabilitation with endurance and strength exercise for 6 weeks (2 supervised sessions/week and daily unsupervised sessions).
Usual care: Standard community care with respirologist
6 months SGRQ, EuroQol, MRC dyspnea scale, shuttle walk test, 3-minute step test, hospital readmission
Nava 1997 [23] 70 COPD patients (mean age 66 years, 73% males, mean FEV1 = 32% predicted, 76% needed mechanical ventilation) admitted to inpatient care for treatment of acute exacerbation. Rehabilitation: Within 3–5 days after admission, inpatient respiratory rehabilitation with four steps of increasing intensity.
Step I, if unable to walk: Mobilisation and strength training for lower extremities.
Step II, if able to walk: Endurance exercise (walking)
Step III, if possible: Endurance exercise (cycling and stair climbing) and respiratory muscle training
IV, if possible: Endurance exercise (cycling at highest tolerated intensity, 2 sessions/day for 3 weeks)
Usual care: Only steps I and II.
6 weeks Dyspnea on exertion, 6 MWT, mortality
Troosters 2002 [25, 26] 48 COPD patients (mean age 62 years, 85% males, FEV1 = 39% predicted) after inpatient treatment for acute exacerbation. Rehabilitation: Outpatient respiratory rehabilitation with endurance and strength exercise for 6 months (3 sessions/week in first 3 months, then 2/week).
Usual care: Standard community care with respirologist.
6 months (6 MWT) and 4 years (survival) 6 MWT, mortality
  1. 6-MWT: 6-minute walk test; CRQ: Chronic Respiratory Questionnaire; SGRQ: St. Georges Respiratory questionnaire; MRC: Medical Research Council