Skip to main content

Table 5 Effects of Stat3 SNPs on repeated measures of PPFEV1 over time*

From: Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

 

Adult Study

CAMP

Stat3 SNPs

β (se)

Additive genetic model p-value‡

FDR threshold (decision§)

β (se)

Additive genetic model p-value‡

G3363a16

     

Intercept (GG)

73.85 (1.21)

    

GT

-2.72 (1.69)

0.008

0.009

---

---

TT

-6.33 (2.46)

 

(reject)

  

rs1026916

     

Intercept (GG)

73.46 (1.13)

  

97.01 (0.93)

 

GA

-2.25 (1.56)

0.028

0.017

-0.19 (0.99)

0.02

AA

-4.74 (2.30)

 

(accept)

-4.24 (1.49)

 

rs957971

     

Intercept (CC)

73.36 (1.16)

    

CG

-1.51 (1.60)

0.036

0.038

---

---

GG

-5.04 (2.29)

 

(reject)

  
  1. * β's obtained from mixed models of repeated measurements of percent predicted FEV1 over time. All models are adjusted for time in weeks, with a maximum of 3 observations for the Adult Study, and 10 observations for the CAMP study. The model for CAMP is adjusted additionally for treatment group.
  2. §Refers to the decision of whether to accept or reject the null hypothesis of no genotype effect. Please see text for further details.