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Table 5 Effects of Stat3 SNPs on repeated measures of PPFEV1 over time*

From: Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

  Adult Study CAMP
Stat3 SNPs β (se) Additive genetic model p-value‡ FDR threshold (decision§) β (se) Additive genetic model p-value‡
G3363a16      
Intercept (GG) 73.85 (1.21)     
GT -2.72 (1.69) 0.008 0.009 --- ---
TT -6.33 (2.46)   (reject)   
rs1026916      
Intercept (GG) 73.46 (1.13)    97.01 (0.93)  
GA -2.25 (1.56) 0.028 0.017 -0.19 (0.99) 0.02
AA -4.74 (2.30)   (accept) -4.24 (1.49)  
rs957971      
Intercept (CC) 73.36 (1.16)     
CG -1.51 (1.60) 0.036 0.038 --- ---
GG -5.04 (2.29)   (reject)   
  1. * β's obtained from mixed models of repeated measurements of percent predicted FEV1 over time. All models are adjusted for time in weeks, with a maximum of 3 observations for the Adult Study, and 10 observations for the CAMP study. The model for CAMP is adjusted additionally for treatment group.
  2. §Refers to the decision of whether to accept or reject the null hypothesis of no genotype effect. Please see text for further details.