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Table 4 Results of linear regression models for baseline PPFEV1*

From: Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

  Adult Study CAMP
Stat3 SNPs β (se)† Additive genetic model p-value‡ FDR threshold (decision§) β (se)† Additive genetic model p-value‡ FDR threshold (decision§)
G3363a16       
Intercept (GG) 74.03 (1.06)    95.67 (0.92)   
GT -3.35 (1.48) 0.0007 0.007 -1.93 (1.25) 0.1 0.02
TT -6.85 (2.15)   (reject) -2.08 (1.84)   (accept)
G3363a4       
Intercept (GG) 70.76 (1.10)    94.19 (0.98)   
GC 1.18 (1.47) 0.3 0.05 1.06 (1.29) 0.6 0.03
CC 2.04 (1.89)   (accept) -2.04 (1.86)   (accept)
rs1026916       
Intercept (GG) 73.59 (0.93)    96.21 (0.95)   
GA -2.90 (1.38) 0.004 0.01 -2.21 (1.33) 0.02 0.007
AA -5.22 (2.03)   (reject) -4.11 (1.90)   (accept)
rs1905340       
Intercept (CC) 73.04 (0.89)    95.52 (0.89)   
CA -3.00 (1.34) 0.04 0.03 -1.18 (1.36) 0.8 0.05
AA -2.77 (2.49)   (accept) 0.70 (2.39)   (accept)
rs957971       
Intercept (CC) 73.48 (1.02)    95.56 (0.01)   
CG -2.10 (1.41) 0.007 0.02 -2.07 (1.26) 0.08 0.01
GG -5.34 (2.00)   (reject) -2.64 (1.91)   (accept)
  1. * Results are from individual linear regression models.
  2. † β 's and p-values are from linear regression models with dummy-coded genotype categories.
  3. ‡ p-values refer to the categorical genotype variable (0, 1, 2), for the number of minor alleles present.
  4. §Refers to the decision of whether to accept or reject the null hypothesis of no genotype effect. Please see text for further details.