Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

Respiratory Research

Table 4 Results of linear regression models for baseline PPFEV₁*

	Adult Study			CAMP
Stat3 SNPs	β (se)†	Additive genetic model p-value‡	FDR threshold (decision§)	β (se)†	Additive genetic model p-value‡	FDR threshold (decision§)
G3363a16
Intercept (GG)	74.03 (1.06)			95.67 (0.92)
GT	-3.35 (1.48)	0.0007	0.007	-1.93 (1.25)	0.1	0.02
TT	-6.85 (2.15)		(reject)	-2.08 (1.84)		(accept)
G3363a4
Intercept (GG)	70.76 (1.10)			94.19 (0.98)
GC	1.18 (1.47)	0.3	0.05	1.06 (1.29)	0.6	0.03
CC	2.04 (1.89)		(accept)	-2.04 (1.86)		(accept)
rs1026916
Intercept (GG)	73.59 (0.93)			96.21 (0.95)
GA	-2.90 (1.38)	0.004	0.01	-2.21 (1.33)	0.02	0.007
AA	-5.22 (2.03)		(reject)	-4.11 (1.90)		(accept)
rs1905340
Intercept (CC)	73.04 (0.89)			95.52 (0.89)
CA	-3.00 (1.34)	0.04	0.03	-1.18 (1.36)	0.8	0.05
AA	-2.77 (2.49)		(accept)	0.70 (2.39)		(accept)
rs957971
Intercept (CC)	73.48 (1.02)			95.56 (0.01)
CG	-2.10 (1.41)	0.007	0.02	-2.07 (1.26)	0.08	0.01
GG	-5.34 (2.00)		(reject)	-2.64 (1.91)		(accept)

* Results are from individual linear regression models.
† β 's and p-values are from linear regression models with dummy-coded genotype categories.
‡ p-values refer to the categorical genotype variable (0, 1, 2), for the number of minor alleles present.
§Refers to the decision of whether to accept or reject the null hypothesis of no genotype effect. Please see text for further details.

ISSN: 1465-993X