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Table 3 BAPTA-AM, SN50 and parthenolide inhibited TNF-α and MIP-2 release in C. pneumoniae infected type II cells

From: Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes

   

BAPTA-AM

SN50

SN50M

parthenolide

C. pneumoniae

-

+

+

+

+

+

TNF-α (3 h)

22.2* ± 7.5

703.4 ± 91

155.5* ± 30.7

122.6* ± 41

705.8 ± 65

125* ± 15.2

MIP-2 (6 h)

211* ± 28

4516 ± 182

2725* ± 413

2436* ± 253

3648 ± 49

1602* ± 24

  1. Mean values are given in pg/ml ± SD of four independent experiments. Asterisk indicates a significant difference (P < 0.0001) compared to C. pneumoniae infected type II cells (column 2) or C. pneumoniae infected type II in the presence of SN50M (column 5).