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Table 3 BAPTA-AM, SN50 and parthenolide inhibited TNF-α and MIP-2 release in C. pneumoniae infected type II cells

From: Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes

    BAPTA-AM SN50 SN50M parthenolide
C. pneumoniae - + + + + +
TNF-α (3 h) 22.2* ± 7.5 703.4 ± 91 155.5* ± 30.7 122.6* ± 41 705.8 ± 65 125* ± 15.2
MIP-2 (6 h) 211* ± 28 4516 ± 182 2725* ± 413 2436* ± 253 3648 ± 49 1602* ± 24
  1. Mean values are given in pg/ml ± SD of four independent experiments. Asterisk indicates a significant difference (P < 0.0001) compared to C. pneumoniae infected type II cells (column 2) or C. pneumoniae infected type II in the presence of SN50M (column 5).